The Envronmental Protection Agency (EPA) designates indoxacarb as having low acute toxicity in humans, and does not cause mutagenic, carcinogenic, developmental or reproductive effects. This document can be found in … Indoxacarb is moderate to very highly toxic in almost all aquatic organisms – with as little as.024 mg/L being lethal to some fish species and important invertebrates. Its chemical name is (S)-methyl 7-chloro-2,5-dihydro-2- [[(methoxycarbonyl) [4-(trifluoromethoxy)phenyl]amino]carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate. D� �/5R;����'�K�(/��UyFz��d�(�z*��A%��S�y�W����l��9����Ê�t��V�A]��/_�C�Z��s�5�k��x=R�lX��h6�f[���,߲|;�o�Hu�c�9�6�< ��>2�8AG�;o�[�iD�w4�@+o� +9�-d�I?�� �02�GJ�F�FO4z� ��r:�r�r7��A0R�~�9�MH&�L#q���7�t��4���6��vK�@�ka�;�:S��|��k���nbإC�٥`�����3�g�����k�߼���������1�Di�zǩ|��o ' r/ Indoxacarb is neurotoxic, as it blocks voltage-dependent sodium channels, resulting in the paralysis and death of insects. The patient was treated successfully with methylene blue and other symptomatic treatments for MetHb. Fig. Truth Publishing International, LTD. is not responsible for content written by contributing authors. Indoxacarb has been classified as a "reduced risk" pesticide by the EPA. It is considered as a “reduced-risk” pesticide which replaces organophosphate pesticides. And in case you have any inquiries or any related concern, feel free to contact us today. 75 0 obj <> endobj ii. h�bbd``b`j�@�� H0� V �u"#�-�,#n�?c�/� ��� Indoxacarb is the active ingredient in the new pet product, Activyl from Merck Animal Health. Further studies are needed in order to determine the exact human body organs that may be affected by indoxacarb. endstream endobj 79 0 obj <>stream In accordance with Article 1 of the Regulation, the rapporteur Member State (RMS), France, and co-rapporteur Member State (co-RMS), Spain, received an application from DuPont de Nemours (Deutschland) GmbH for the renewal of approval of the active substance indoxacarb. h�b```f``bg`d``�e�a@ &�GCn��d�_����$sZ/$5M��o����jժ��m���pkC����4��E����K �LNHi��� �!� %PDF-1.6 %���� indoxacarb (ISO); methyl (4aS)-7-chloro-2-{(methoxycarbonyl)[4-(trifluoromethoxy ... assigned graphical indicators for certain substance properties that are regarded as being of relevance or importance to human health and/or the environment based on the information provided ... More information about reproductive toxicity here. Indoxacarb is readily absorbed after oral ingestion and extensively metabolised by the liver. 25 The active metabolite binds to and blocks voltage-dependent sodium channels within the insect nervous system, resulting in paralysis and death of the insect. Therefore, it can be substantiated that indoxacarb, an oxidiazine insecticide, also manifests its toxicity in humans in the form of methemoglobinaemia. Truth Publishing assumes no responsibility for the use or misuse of this material. Thursday, November 30, 2017 by Rita Winters, http://www.naturalpedia.com/indoxacarb-toxicity-side-effects-diseases-and-environmental-impacts.html. It is not intended as a substitute for professional advice of any kind. Indoxacarb is highly effiective,low-toxicity insecticide for use in agriculture. Toxicity to humans. endstream endobj 76 0 obj <> endobj 77 0 obj <> endobj 78 0 obj <>stream MetHb disables hemoglobin and methemoglobin from releasing oxygen into the organs, which results in the discoloration of blood and the bluish tint of the skin. This degradate has a higher toxicity than the parent indoxacarb (Brugger, 1997). Indoxacarb has low acute toxicity. When chemical dust is inhaled, transfer the victim to an open area with fresh air. Indoxacarb does not bioaccumulate. When lepidopteran larvae ingest sprayed foliage or are sprayed The difference in oral toxicity between the The toxicity database for indoxacarb is complete. The side effects include, but are not limited to, nasal and ocular discharge, immobility, lethargy, tremors, spasms, salivation and rapid weight loss. iii. In case of indoxacarb poisoning, follow the necessary first aid measures to attend to the victim. Pesticide properties for Indoxacarb, including approvals, environmental fate, eco-toxicity and human health issues Search for: Subchronic, Chronic, Carcinogenicity, Developmental, Reproductive, and Mutagenic Toxicity Indoxacarb has been classified as a “not likely” human carcinogen. It is marketed to kill fleas on dogs and cats. 1. Introduction. To avoid inhalation, use proper respiratory gear. Occupational exposure to indoxacarb may occur through inhalation and dermal contact with this compound at workplaces where indoxacarb is produced or used. When skin or eye contact occurs, flush the affected area with clean water. Furthermore, the labels should clearly specifY that the recommended aplication rates for the listed crops are based on the concentration of S­ indoxacarb. For all cases mentioned, seek medical attention as soon as possible. Mechanism of Toxicity. Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. 81 0 obj <>/Filter/FlateDecode/ID[<417974CA64DEEBCB0177CA57E95E5A2B>]/Index[75 15]/Info 74 0 R/Length 53/Prev 48182/Root 76 0 R/Size 90/Type/XRef/W[1 2 1]>>stream Your use of this website indicates your agreement to these terms and those published here. ACUTE HUMAN TOXICITY - Risk Assessment Acute Toxicity Testing and Ecotoxicity Summary: Honey bee or insect (LD50) Mammalian (LD50) 0.18 ug/bee 179 mg/kg (KN128) 1 1 ... high in hazard but because indoxacarb is an insecticide and toxicity to bees and insects is expected and therefore not part of the pesticide review. In insects, indoxacarb is absorbed via ingestion with lesser amounts absorbed across the insect cuticle, and it is bioactivated by the cleaving of a carbomethoxy group from the parent compound. It acts on insects by blocking sodium channels in the nervous system, ceasing the organisms’ feeding and causing immobility, resulting in death in a few hours. hޔ��n�8�_�/��q(8����jhQ�F7��'��5�� 6���Ό�#�s1�(�W�\���R���X̮E��gY��J���]�by1>��%~�E�֟vE6���77p�l����٧_-�S�*�ީ��pw{|���d��?����'���(Ì�� It is characterized by weakness, head tilting, and abnormal gait or mobility with inability to stand. In the acute toxicity studies, indoxacarb is toxic by oral route, harmful by inhalation and is of low toxicity dermally.3 3 Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006. Indoxacarb is a new active substance to the EU, and as such, there is no current classification assigned according to Annex I of Council Directive 67/548/EEC. Table 2.1 Applicant’s proposed classification for DPX-KN128 The acute neurotoxicity, subchronic toxicity, and developmental neurotoxicity studies for indoxacarb are available and all endpoints used in the risk assessment are protective of neurotoxic effects. While toxicity to humans has not been formally studied there have been reports of people trying to consume indoxacarb in suicide attempts. Other names for indoxacarb include Indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylic acid, 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoromethoxy)phenyl]amino]carbonyl]-, methyl ester, (4aS)-; and methyl (4aS)-7-chloro-2-{(methoxycarbonyl)[4-(trifluoromethoxy)phenyl]carbamoyl}-2,5-dihydroindeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate. i. There is limited data concerning the human toxicity of indoxacarb. Indoxacarb residue may be found in cotton, brassicas, sweet corn, lettuce, fruiting vegetables, fruits including apples, pears and cherries. amanda@awiner.com 2020-11-19T10:59:18+00:00. He was managed conservatively with fluid management, antibiotics, mechanical ventilation and physiotherapy. Polygonograms showing the toxicological interactions of the indoxacarb (I) in binary combinations with lufenuron (L), methoxyfenozide (M), chlorpyrifos (Ch), profenofos (Pr), and lambda-cyhalothrin (Cy). Most rats died 20 days after being dosed with indoxacarb, and the few that survived showed the poisoning symptoms listed above. There is no accumulation in tissues and the metabolites are excreted in the faeces and urine. Indoxacarb degrades well in soil under aerobic conditions (half-life 18 to 34 days), but under anaerobic conditions it is quite persistent. 0 Other trade names may include Advion, Arilon, and Avent. 89 0 obj <>stream The reported field dissipation half-lives of indoxacarb are Occupational exposure to this substance may also occur during loading and application. of S-indoxacarb (75% insecticidally active enantiomer) and R-indoxacarb (25% insecticidally inactive enantiomer). Indoxacarb (DPX-MP062) has low acute oral toxicity (LD50= 1730 mg/kg bw) in male rats and moderate oral toxicity (LD50= 268 mg/kg bw) in female rats, and low dermal (LD50> 5000 mg/kg bw) and inhalation toxicity (DPX-JW062; LC50= 4200 mg/m3 (4.2 mg/L) in rats. 1. 88 of … Together with hemoglobin, methemoglobin is responsible for absorbing oxygen and delivering it to different parts of the body. All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners. One report shows that indoxacarb is a serious health detriment to humans. 1 However, information concerning its human toxicity is as yet limited. As in our patient, it could be successfully managed with intravenous methylene blue and other supportive and symptomatic treatment. Indoxacarb has low oral toxicity in male rats, moderate oral toxicity in female rats, and low dermal and inhalation toxicity in rats. 7) It also exerts human toxicity characterized by blurred vision, skin sensitization, and alteration in blood cell count. This site is part of the Natural News Network © 2012 All Rights Reserved. GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] A 48-year old farmer ingested indoxacarb as a suicidal attempt. This chemical may be lethal to humans, especially when ingested. 5 6 Manufacturing process information may be entitled to confidential treatment The Envronmental Protection Agency (EPA) designates indoxacarb as having low acute toxicity in humans, and does not cause mutagenic, carcinogenic, developmental or reproductive effects. Indoxacarb shows low persistence in aquatic systems. endstream endobj startxref Indoxacarb undergoes rapid decomposition in terrestrial environments through microbial degradation (Brugger, 1997). Toxicity of second instar larvae of Spodoptera littoralis to indoxacarb, lufenuron, methoxyfenozide, chlorpyrifos, profenofos, and lambda-cyhalothrin at 72 h post-treatment. Indoxacarb may cause death when ingested. Materials and Methods Animals … This case demonstrates that findings from animal studies, such as seizures, respiratory distress, and intravascular hemolysis are possible following self-poisoning in humans. Indoxacarb blocks the movements of sodium ions in nerve cells which results in paralysis, and subsequently, death of the affected organism. Indoxacarb is a newly developed oxadiazine insecticide that acts by blocking sodium channels in insects’ nervous systems. Super mosquitoes with insecticide resistance discovered in Mali, Glucophage – uses, health risks, and side effects at NaturalPedia.com, Norvasc – uses, health risks, and side effects at NaturalPedia.com, Blackcurrant seed oil sources, health benefits and uses, Sandimmune – uses, health risks, and side effects at NaturalPedia.com. Indoxacarb is moderately to highly toxic to fish and invertebrates. toxicity and safety of Activyl® in dogs, as well as assessed the potential of human health exposure by determining the residue of permethrin and indoxacarb in the dog’s blood and in gloves worn while petting the dogs. Indoxacarb is an oxadiazine insecticide which targets lepidoptera, including beet armyworms, fire ants, and cockroaches. Indoxacarb is an oxadiazine insecticide with a limited number of reports concerning its human toxicity. Neurotoxicity was observed in several studies in both rats and mice. Avoid skin and eye contact by wearing chemical gloves, boots, coveralls and goggles. |���2��QKv�a�?��^��=Z���/��JAi�RW|��M��I坅�G�T.J��F�4�A��6����Hh�m�O��)�k��'P2�DA��k��\$�6�����~�!����U}��5�q���Ձch�>�b*�4��=��c�R����$mzW�5um��ɧ5��~�u�Ʊ��8��ր��dh��1��v�?AxS ��$�>�:��N-����w��%��{B{����דQ�x,}Uc���D_���F+i��О�-Z���@����+lM Indoxacarb is one of the active substances listed in Regulation (EU) No 686/2012. In case of ingestion, transport the victim to the nearest emergency department. Under aerobic conditions, the hydrolysis product INJT333 is rapidly formed (Figure 1). Fenoxycarb: Fenoxycarb is use in products targeting fire ants, packaged as granular formulations. I hope it is helped for you. This chemical targets the central nervous system. 12.1 Toxicity no data available Toxicity to fish LC50 - Oncorhynchus mykiss (rainbow trout) - 0,65 mg/l - 96,0 h 12.2 Persistence and degradability no data available 12.3 Bioaccumulative potential no data available 12.4 Mobility in soil no data available 12.5 Results of PBT and vPvB assessment no data available 12.6 Other adverse effects However, 108 out of 111 companies state that indoxacarb should be labeled with acute toxicity, irritant, health hazard and environmental toxicity. It breaks down quickly when exposed to sunlight. It has low acute toxicity and is not well absorbed through the skin, but with longer-term exposure, it is toxic to the liver and is a Probable carcinogen. Human Health Risk Assessment for Indoxacarb to Support the Proposed New Use on Almond Hulls and Tree Nut Group 14-12,” dated August 20, 2020. The Applicant’s proposal for the classification of indoxacarb is given in Table 2.1. This case demonstrates that the findings noted in animal studies, such as seizures, respiratory distress, and intravascular hemolysis may occur following self-poisoning in humans. H��V[s�F~׌��yD�a/��7E����U�4�H~����H�"�Z}�?o�. Indoxacarb has only moderate to low toxicity, meaning that it does not cause carcinogenic, mutagenic, or developmental effects in people or pets when used in residential and commercial areas. While research has shown that indoxacarb is highly toxic to the aquatic ecosystem, the chemical is hydrophobic and breaks down in water over time. The farmer developed peripheral cyanosis and muddy-brown discoloration of blood, a result of methemoglobinemia (MetHb). Indoxacarb, the active ingredient in DuPont™ Steward ... human health, low toxicity to non-target organisms (birds, fish and plants), low potential for groundwater contamination, lower use rates, low pest resistance potential and compatibility with Integrated Pest Management programs. There are limited data concerning the human toxicity of indoxacarb. In this patient, … These items are the registered uses for indoxacarb. AB - The use of selective insecticides may improve conservation of natural enemies and therefore contribute to the success of integrated pest management (IPM) programs. The indoxacarb content shall be declared (not less than 900 g/kg) and, when determined, the average measured content shall not be lower than the declared minimum content. Indoxacarb is especially active on foliar-feeding lepidopteran larvae; oral toxicity was 0.01 and 0.03 ng/mg body weight for Heliothis virescens (F.) and Spodoptera frugiperda (Smith), respectively (Wing et al., 2000). Laboratory tests show that indoxacarb, through various routes of exposure, causes negative side effects in rats, mice, rabbits and dogs. We present here a case of a methemoglobinemia following deliberate ingestion of Indoxacarb during an attempt at suicide. ��d�Й��=�|����K�q8x�nI�q?P�`8�\�N@� |�xlN�P���a8p��o���>8��˞�((x�'…d����i1�h��DϜr�Gз��'���=.3|�]L������S�������냩�k���8�ua_)������j>zM=G����"��pi΀B���q���/*H�� �C�����_��E��p��>�Y�RXVq��#�2� ���!K�(��WY�_�B��,�R�����!l�y8�CS�n>M�Y�%+�|�A�-�+*��p#��NJ���)K`y��Wq��ѣW]�DG?�<9b������븓���Fc�z�Y��>����s�$�8�$�|q��k������[��~U�b��k�F�n����9��`]NK�Y�㤂�F�ʘ����U���6_Mžp�+ ���ʺ�w�8���eI�}�i�'qy�K$���D���}oU�/rx(J���&�O����[S��P��I��^���+`���;���wo�n�.�3F8{a��}۴������D�~�l�dd������6\D��5��a�~�!���w��׆%.��&�/��;�����6{d3A}�]���ީjs܂��Ͷ(�]�v�m����a�Z[ڤx:���q��J�u"�n�i��1�2{�0R�}�(���wY^ܵA�. Proper precaution must be observed when using or handling indoxacarb. However, 108 out of 111 companies state that indoxacarb should be labeled with acute toxicity, irritant, health hazard and environmental toxicity. Indoxacarb is known to cause methemoglobemia, a blood disorder. MetHb is a blood disorder in which an abnormal amount of methemoglobin is produced. %%EOF This chemical is produced by DuPont and marketed in the U.S. as StewardTM, AvauntTM, and Technical IndoxacarbTM. Implications of the toxicity of indoxacarb to H. axyridis within an IPM context and possible reasons for the differences in susceptibility of H. axyridis for each route of exposure are discussed. The information on this site is provided for educational and entertainment purposes only. , low-toxicity insecticide for use in products targeting fire ants, and subsequently death... A `` reduced risk '' pesticide by the liver, follow the necessary first aid measures to attend to nearest... The few that survived showed the poisoning symptoms listed above produced or used and dermal with... To 34 days ), but under anaerobic conditions it is considered as a “reduced-risk” pesticide which replaces organophosphate.! The parent indoxacarb ( Brugger, 1997 ) content posted on this site is part of the area. Rabbits and dogs which an abnormal amount of methemoglobin is responsible for content written by authors... And mice where indoxacarb is moderately to highly toxic to fish and invertebrates medical as. By the EPA mechanical ventilation and physiotherapy and muddy-brown discoloration of blood, a disorder. Of methemoglobinaemia for MetHb of S-indoxacarb ( 75 % insecticidally inactive enantiomer ) materials and Methods …! Humans has not been formally studied there have been reports of people trying to consume indoxacarb in attempts! Toxicity than the parent indoxacarb ( Brugger, 1997 ) in several studies in rats. Observed in several studies in both rats and mice soon as possible % insecticidally inactive )... 18 to 34 days ), but under anaerobic conditions it is considered as a substitute for advice. To attend to the victim conditions it is not intended as a suicidal attempt should. That survived showed the poisoning symptoms listed above on dogs and cats case you any! Order to determine the exact human body organs that may be affected by indoxacarb of insects been formally studied have. There have been reports of people trying to consume indoxacarb in suicide attempts truth assumes!, mechanical ventilation and physiotherapy human body organs that may be affected by.... Indoxacarb, an oxidiazine insecticide, also manifests its toxicity in rats, moderate toxicity... Provided for educational and entertainment purposes only present here a case of a methemoglobinemia following deliberate of... Results in paralysis, and the metabolites are excreted in the U.S. as,... Of 111 companies state that indoxacarb should be labeled with acute toxicity,,... Reduced risk '' pesticide by the liver ) and R-indoxacarb ( 25 % inactive... Kill fleas on dogs and cats wearing chemical gloves, boots, coveralls and goggles suicidal! As soon as possible indoxacarb human toxicity the poisoning symptoms listed above and physiotherapy workplaces indoxacarb... Laboratory tests show that indoxacarb, and alteration in blood cell count rabbits and dogs the movements of sodium in! Rapidly formed ( Figure 1 ) low-toxicity insecticide for use in products targeting fire ants, and low dermal inhalation. And eye contact occurs, flush the affected organism developed oxadiazine insecticide which targets lepidoptera, including armyworms! Marketed to kill fleas on dogs and cats movements of sodium ions in cells... To indoxacarb may occur through inhalation and dermal contact with this compound at workplaces where indoxacarb is in. News Network © 2012 all Rights Reserved … Thursday, November 30, 2017 by Rita Winters, http //www.naturalpedia.com/indoxacarb-toxicity-side-effects-diseases-and-environmental-impacts.html! Affected organism in agriculture case you have any inquiries or any related concern, feel free to contact us.! Has not been formally studied there have been reports of people trying to consume indoxacarb suicide... Order to determine the exact human body organs that may be lethal to has. Listed above oral toxicity in rats, and low dermal and inhalation toxicity in rats abnormal gait or with... Risk '' pesticide by the EPA moderately to highly toxic to fish and invertebrates peripheral. Should clearly specifY that the recommended aplication rates for the use or misuse of this material replaces pesticides. S­ indoxacarb metabolites are excreted in the form of methemoglobinaemia with acute toxicity, irritant health! Of reports concerning its human toxicity characterized by blurred vision, skin sensitization, and subsequently, indoxacarb human toxicity! Be affected by indoxacarb the EPA highly toxic to fish and invertebrates of insects the News. Names may include Advion, Arilon, and cockroaches property of their respective owners of.., resulting in the paralysis and death of insects mice, rabbits and dogs produced by DuPont and marketed the. … indoxacarb is moderately to highly toxic to fish and invertebrates ants, packaged as granular.! Fenoxycarb is use in agriculture affected by indoxacarb further studies are needed order! Flush the affected area with clean water precaution must be observed when using indoxacarb human toxicity! Dogs and cats flush the affected area with fresh air produced or used in products targeting fire ants and... Our patient, it could be successfully managed with intravenous methylene blue and other supportive and symptomatic treatment neurotoxic as... ’ nervous systems successfully with methylene blue and other symptomatic treatments for MetHb under conditions! Absorbed after oral ingestion and extensively metabolised by the EPA classification for DPX-KN128 indoxacarb is given Table. Contributing authors poisoning, follow the necessary first aid measures to attend to the emergency! There is no accumulation in tissues and the few that survived showed the poisoning symptoms listed above, out! Insecticide for use in products targeting fire ants, and subsequently, death of insects days after dosed... Its toxicity in male rats, moderate oral toxicity in male rats, mice, rabbits dogs. To this substance may also occur during loading and application case you have any inquiries any. A suicidal attempt in paralysis, and Technical IndoxacarbTM ingestion of indoxacarb poisoning, follow necessary... Indoxacarb is an oxadiazine insecticide with a limited number of reports concerning its human toxicity in male rats,,! A substitute for professional advice of any kind with a limited number of reports its... Dermal contact with this compound at workplaces where indoxacarb is an oxadiazine insecticide with a limited number of reports its! Advice of any kind conditions it is considered as a `` reduced ''. Is neurotoxic, as it blocks voltage-dependent sodium channels in insects ’ nervous systems reduced risk '' by. Metabolised indoxacarb human toxicity the liver ( Brugger, 1997 ) the exact human body organs may! In male rats, mice, rabbits and dogs to indoxacarb may through! Inactive enantiomer ) and R-indoxacarb ( 25 % insecticidally active enantiomer ) risk '' pesticide by EPA. Studied there have been reports of people trying to consume indoxacarb in suicide.... Indoxacarb is produced or used and servicemarks mentioned on this site are the property of their respective owners the! In male rats, moderate oral toxicity in male rats, mice, and... Ingest sprayed foliage or are sprayed indoxacarb is highly effiective, low-toxicity insecticide for use in targeting! You have any inquiries or any related concern, feel free to contact us today by Rita Winters,:! Attempt at suicide the Natural News Network © 2012 all Rights Reserved S­.!